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Cum îmbunătățește combinația de CBD și THC tratamentul migrenelor cronice prin afectarea inflamației neurovasculare?

Cum îmbunătățește combinația de CBD și THC tratamentul migrenelor cronice prin afectarea inflamației neurovasculare? CBD și THC reduc inflamația neurovasculară prin modularea sistemului endocannabinoid și a altor căi de semnalizare implicate în patofiziologia migrenei. THC se leagă de receptorii CB1, reducând eliberarea de neuropeptide precum CGRP care contribuie la durerea și inflamația migrenei. CBD completează acest lucru prin reducerea stresului oxidativ și modularea receptorilor TRPV1, care sunt implicați în semnalizarea durerii. Împreună, ele scad frecvența și intensitatea migrenelor abordând atât componentele inflamatorii, cât și cele vasculare. Această combinație oferă o abordare cu mai multe fațete a managementului migrenei cronice.
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