How does the extraction method of cannabinoids influence their potency and therapeutic efficacy?
How does the extraction method of cannabinoids influence their potency and therapeutic efficacy? The extraction method of cannabinoids significantly influences their potency and therapeutic efficacy by determining the purity, bioavailability, and overall chemical profile of the final product. Different extraction techniques, such as ethanol extraction, CO2 extraction, and solventless methods, can yield varying concentrations of cannabinoids and terpenes, impacting their synergistic effects. For instance, supercritical CO2 extraction is known for producing high-quality extracts with preserved terpenes, enhancing the entourage effect and therapeutic outcomes. Additionally, the choice of extraction method can affect the presence of contaminants, such as solvents or pesticides, which may compromise product safety and efficacy. Therefore, selecting appropriate extraction methods is crucial for developing effective cannabinoid formulations (Crippa et al., 2019).