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How does the interaction between cannabinoids and the skin’s microbiome influence the effectiveness of transdermal delivery?

How does the interaction between cannabinoids and the skin’s microbiome influence the effectiveness of transdermal delivery? Cannabinoids can interact with the skin's microbiome, potentially affecting skin health and the absorption of cannabinoids through the skin. The skin microbiome may alter the metabolism of cannabinoids, influencing their therapeutic effects and absorption rates. An imbalance in the skin’s microbiome could affect the skin's barrier function, leading to either enhanced or reduced cannabinoid absorption. Understanding these interactions is crucial for optimizing the design of CBD patches for targeted therapeutic outcomes.

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