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How does the molecular structure of cannabinoids influence their ability to bind to skin receptors in CBD patch applications?

How does the molecular structure of cannabinoids influence their ability to bind to skin receptors in CBD patch applications? The molecular structure of cannabinoids like CBG, CBD, and CBN influences their binding affinity to skin receptors, such as TRPV1 or CB2, involved in pain, inflammation, and other skin responses. The size, polarity, and functional groups on the cannabinoid molecules determine how they interact with receptors, affecting their therapeutic efficacy. Cannabinoids with structures that more closely resemble endogenous compounds are often more effective at binding to these receptors. This interaction is crucial for maximizing the therapeutic potential of cannabinoids when applied through transdermal patches.

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