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How does the pharmacology of cannabinoids change with age, and what implications does this have for elderly patients?

How does the pharmacology of cannabinoids change with age, and what implications does this have for elderly patients? The pharmacology of cannabinoids can change with age due to alterations in metabolism, receptor sensitivity, and overall physiological changes that occur as individuals grow older. Elderly patients may experience different effects from cannabinoids, including enhanced sensitivity to psychoactive effects and alterations in drug metabolism, necessitating careful dosing and monitoring. Additionally, older adults often have comorbidities and take multiple medications, which can lead to increased risks of drug interactions. Understanding these age-related changes is crucial for healthcare providers to optimize cannabinoid therapies in elderly patients, ensuring both safety and efficacy. Ongoing research is essential to develop age-appropriate guidelines for cannabinoid use in older populations (Mason et al., 2020).
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