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What are the implications of cannabinoid receptor polymorphisms on individual responses to cannabis?

What are the implications of cannabinoid receptor polymorphisms on individual responses to cannabis? Cannabinoid receptor polymorphisms can significantly influence individual responses to cannabis, impacting efficacy and side effects experienced by users. Variations in the genes encoding cannabinoid receptors, particularly the CB1 receptor, can affect receptor sensitivity and signaling pathways, leading to divergent responses to cannabinoids like THC. For instance, individuals with specific polymorphisms may experience heightened psychoactive effects or increased susceptibility to adverse reactions, influencing their therapeutic experience. Understanding these genetic factors can help tailor cannabinoid treatments to individual profiles, improving efficacy and safety in clinical applications. Genetic screening may emerge as a valuable tool in personalizing cannabis-based therapies for various medical conditions (Turan et al., 2019).
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