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What role does the entourage effect play in the overall efficacy of cannabinoid formulations?

What role does the entourage effect play in the overall efficacy of cannabinoid formulations? The entourage effect refers to the synergistic interactions between cannabinoids, terpenes, and other compounds in cannabis, which can enhance the overall efficacy of cannabinoid formulations. Research suggests that the presence of multiple cannabinoids and terpenes may amplify therapeutic effects while minimizing side effects compared to isolated cannabinoids. For example, the combination of THC and CBD has been shown to improve analgesic and anti-inflammatory outcomes, demonstrating the potential benefits of using whole-plant formulations. Understanding the entourage effect is critical for developing cannabinoid products that maximize therapeutic benefits and tailor treatments to individual patient needs. This holistic approach to cannabis formulation can enhance patient outcomes and satisfaction (Russo, 2011).
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