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Miten kannabinoidien transdermaalinen annostelu verrattuna suonensisäiseen antoon systeemisten vaikutusten vuoksi?

Miten kannabinoidien transdermaalinen annostelu verrattuna suonensisäiseen antoon systeemisten vaikutusten vuoksi? Transdermaaliset laastarit imeytyvät asteittain ja säilyttävät vakaat veren tasot ajan mittaan, kun taas suonensisäinen (IV) annostelu johtaa välittömiin huippupitoisuuksiin plasmassa. Suonensisäinen annostelu varmistaa 100 %:n biologisen hyötyosuuden, mutta sen kesto on lyhyt ja vaatii lääkärin valvontaa. Laastarit vähentävät toistuvan annostelun tarvetta ja minimoivat lääketasojen vaihtelut. Vaikka IV on paras akuuteille vaikutuksille, transdermaalinen annostelu on parempi jatkuvan terapeuttisen hyödyn kannalta (Paudel et al., 2010).

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