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Kako CBD modulira učinke THC-a na kroničnu bol preko perifernih CB1 i CB2 receptora?

Kako CBD modulira učinke THC-a na kroničnu bol preko perifernih CB1 i CB2 receptora? CBD modulira učinke THC-a na kroničnu bol interakcijom s perifernim CB1 i CB2 receptorima, pojačavajući analgetska svojstva THC-a uz smanjenje nuspojava. THC prvenstveno djeluje na CB1 receptore u središnjem živčanom sustavu kako bi smanjio percepciju boli, ali također utječe na periferne CB1 i CB2 receptore u imunološkim stanicama i tkivima uključenima u signalizaciju boli. CBD, koji ima nizak afinitet za CB1 receptore, ali jak afinitet za CB2 receptore, pojačava protuupalne i analgetske učinke THC-a modulirajući imunološke odgovore u perifernom živčanom sustavu. Sposobnost CBD-a da regulira imunološki odgovor i smanji neuroinflamaciju doprinosi sinergističkim učincima THC-a i CBD-a za upravljanje kroničnom boli. Kombinacija nudi sveobuhvatan pristup ublažavanju boli djelujući i na središnje i na periferne puteve boli.

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IMPORTANT: This information is NOT MEDICAL ADVICE and is only provided for general informational purposes only. Always first seek the advice of your doctor or a healthcare professional first before taking a CBD product or vitamin supplement if you are unsure. Statements regarding dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease or health condition. No claims are intended to be made about the functions or ability of a CBD infused cosmetic product and/ or vitamin supplement to provide any specific health or wellness benefits. None of our CBD strips, patches or other CBD products are described, promoted or marketed as having any function not listed in the COSING Information Database. Any information provided here about CBD or any other ingredient and/ or product is strictly for general informational purposes and should not be interpreted as medical, therapeutic, or diagnostic advice. CBD products are not intended to diagnose, treat, cure, or prevent any disease or health condition. You are advised to always first consult with a doctor or a qualified healthcare professional before using any CBD product, particularly if you any of the following apply. DO NOT USE CBD IF PREGANT, BREAST FEEDING OR IF YOU HAVE A SERIOUS MEDICAL CONDITION. DO NOT USE IF PACKAGING HAS BEEN OPENED DURING SHIPPING. DISCONTINUE USE IF ANY ADVERSE REACTION OR SYMPTOM OCCURS. CONTACT A DOCTOR IF REACTION OR SYMPTOM CONTINUES. FOR ADULTS ONLY. STORE OUT OF REACH OF CHILDREN.