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Koji su molekularni mehanizmi THC-inducirane analgezije?

Koji su molekularni mehanizmi THC-inducirane analgezije? THC izaziva analgeziju prvenstveno aktivacijom CB1 receptora u središnjem živčanom sustavu i CB2 receptora u perifernim tkivima. Vezanjem na CB1 receptore, THC smanjuje oslobađanje neurotransmitera, osobito u putevima boli kao što je spinotalamički trakt, čime se smanjuje osjećaj boli. THC također utječe na otpuštanje upalnih citokina, smanjujući upalu i doprinoseći ublažavanju boli. Entourage učinak s drugim kanabinoidima i terpenima može dodatno pojačati analgetske učinke THC-a. Uloga THC-a u kontroli boli posebno je korisna kod neuropatske boli, artritisa i drugih kroničnih bolnih stanja.

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