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Come fa il corpo a metabolizzare il THC per creare effetti psicoattivi?

Come fa il corpo a metabolizzare il THC per creare effetti psicoattivi? Quando il THC viene ingerito o inalato, viene assorbito nel flusso sanguigno e viaggia verso il fegato, dove viene metabolizzato in 11-idrossi-THC, un composto significativamente più potente del THC stesso. Questo metabolita viene poi fatto circolare in tutto il corpo, compreso il cervello, dove si lega ai recettori CB1 del sistema endocannabinoide, producendo effetti psicoattivi. Il metabolismo del THC in 11-idrossi-THC contribuisce agli effetti più forti e più duraturi degli edibili rispetto al fumo o allo svapo, dove il THC viene assorbito più rapidamente nel flusso sanguigno senza subire un metabolismo significativo nel fegato. La velocità e l'intensità degli effetti psicoattivi del THC dipendono dalla rapidità ed efficienza con cui il corpo metabolizza il composto.

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