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Come può il gradiente di concentrazione tra il cerotto e la pelle migliorare o ostacolare la diffusione dei cannabinoidi attraverso la pelle?

Come può il gradiente di concentrazione tra il cerotto e la pelle migliorare o ostacolare la diffusione dei cannabinoidi attraverso la pelle? Il gradiente di concentrazione tra il cerotto e la pelle è fondamentale per la diffusione dei cannabinoidi. Una maggiore concentrazione di cannabinoidi nel cerotto rispetto alla pelle guida il processo di diffusione, migliorando l'assorbimento. Tuttavia, se il gradiente è troppo ripido, una diffusione rapida può portare a dosi iniziali elevate che la pelle potrebbe non assorbire in modo efficiente. Al contrario, un gradiente più debole può comportare un assorbimento più lento, riducendo l’efficacia terapeutica. Una formulazione adeguata e un design del cerotto aiutano a gestire questo gradiente per un rilascio ottimale dei cannabinoidi.

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