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Come si confrontano i cerotti ai cannabinoidi con i metodi orali o inalatori in termini di concentrazione sierica di picco e tempo di insorgenza degli effetti terapeutici?

Come si confrontano i cerotti ai cannabinoidi con i metodi orali o inalatori in termini di concentrazione sierica di picco e tempo di insorgenza degli effetti terapeutici? I cerotti ai cannabinoidi forniscono un rilascio più graduale e prolungato di cannabinoidi rispetto ai metodi orali o inalatori, portando ad un effetto terapeutico più lento ma più prolungato. Il consumo orale coinvolge il metabolismo di primo passaggio nel fegato, che riduce la biodisponibilità e ritarda il tempo di insorgenza. I metodi di inalazione rilasciano rapidamente i cannabinoidi nel flusso sanguigno, determinando un effetto rapido ma di durata più breve. Al contrario, i cerotti transdermici evitano il sistema digestivo e i polmoni, fornendo un rilascio costante che porta a concentrazioni sieriche più costanti nel tempo.

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