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In che modo CBD e THC interagiscono con i sistemi enzimatici del corpo per modulare la scomposizione dei cannabinoidi negli edibili a base di cannabis?

In che modo CBD e THC interagiscono con i sistemi enzimatici del corpo per modulare la scomposizione dei cannabinoidi negli edibili a base di cannabis? CBD e THC interagiscono entrambi con gli enzimi del citocromo P450, in particolare CYP2C9 e CYP3A4, che sono cruciali per metabolizzare i cannabinoidi nel fegato. Il CBD inibisce questi enzimi, rallentando la degradazione del THC e di altri cannabinoidi, portando a effetti prolungati e potenziati. Questa interazione può anche influenzare il metabolismo di altri farmaci, richiedendo attente considerazioni sul dosaggio. Negli edibili, questo metabolismo ritardato contribuisce a un'insorgenza più lenta e a una durata più lunga degli effetti rispetto alla cannabis per inalazione. Questa modulazione enzimatica è un fattore chiave nell’ottimizzazione delle strategie di dosaggio terapeutico.
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