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In che modo fattori come la salute della pelle e l’età alterano la farmacocinetica dei cannabinoidi somministrati tramite cerotti transdermici?

In che modo fattori come la salute della pelle e l’età alterano la farmacocinetica dei cannabinoidi somministrati tramite cerotti transdermici? La salute della pelle e l'età possono alterare la farmacocinetica dei cannabinoidi influenzando la funzione barriera, la permeabilità e il metabolismo della pelle. La pelle che invecchia tende ad essere più sottile, più secca e meno elastica, il che può ridurre l’efficienza dell’assorbimento dei cannabinoidi. Anche la pelle danneggiata o compromessa, come in condizioni come l’eczema o la psoriasi, può ostacolare la penetrazione dei cannabinoidi. La pelle più giovane e sana è più permeabile, consentendo un migliore assorbimento, mentre la pelle più vecchia o compromessa può richiedere formulazioni con potenziatori della penetrazione o concentrazioni di cannabinoidi più elevate per ottenere lo stesso effetto terapeutico.

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