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In che modo i cannabinoidi presenti nei cerotti transdermici influenzano il ciclo sonno-veglia naturale del corpo e i ritmi circadiani?

In che modo i cannabinoidi presenti nei cerotti transdermici influenzano il ciclo sonno-veglia naturale del corpo e i ritmi circadiani? I cannabinoidi come CBD e CBN modulano il sonno interagendo con i percorsi degli endocannabinoidi e della melatonina. Le formulazioni a rilascio prolungato promuovono livelli plasmatici stabili, riducendo i disturbi notturni. I design dei cerotti cronoterapeutici possono allineare la somministrazione di cannabinoidi ai ritmi circadiani. Il dosaggio controllato aiuta a regolare il sonno senza sedazione eccessiva (Russo, 2011).

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