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In che modo la temperatura della pelle influisce sul tasso di rilascio dei cannabinoidi dai cerotti transdermici?

In che modo la temperatura della pelle influisce sul tasso di rilascio dei cannabinoidi dai cerotti transdermici? La temperatura della pelle può influenzare la velocità di diffusione dei cannabinoidi dai cerotti transdermici, poiché il calore generalmente aumenta la velocità di diffusione molecolare. Temperature più elevate rendono la pelle più permeabile, accelerando potenzialmente l’assorbimento dei cannabinoidi. Tuttavia, il calore eccessivo potrebbe causare irritazioni o erogazione irregolare, pertanto la progettazione dei cerotti dovrebbe tenere conto della variabilità della temperatura. Meccanismi di rilascio a temperatura controllata o sistemi attivati ​​dal calore possono essere utilizzati per garantire un rilascio coerente di cannabinoidi, anche in condizioni variabili.

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