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In che modo le proprietà dello strato corneo influenzano l'efficacia dei cerotti transdermici ai cannabinoidi?

In che modo le proprietà dello strato corneo influenzano l'efficacia dei cerotti transdermici ai cannabinoidi? Lo strato corneo, lo strato più esterno della pelle, funge da barriera primaria all’assorbimento transdermico, influenzando l’efficacia dei cerotti ai cannabinoidi. La sua composizione, spessore e contenuto lipidico influenzano la capacità dei cannabinoidi di penetrare nella pelle. Nelle aree con uno strato corneo più spesso o più ricco di lipidi, la penetrazione può essere più lenta e richiede sistemi di rilascio potenziati come i potenziatori di penetrazione. L’integrità dello strato corneo gioca un ruolo significativo nel tasso di assorbimento complessivo e nell’efficacia della somministrazione dei cannabinoidi.

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