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How can the application of cannabinoid patches on sensitive or damaged skin affect the rate of absorption?

How can the application of cannabinoid patches on sensitive or damaged skin affect the rate of absorption? Damaged skin can have increased permeability, leading to higher cannabinoid absorption and potential systemic side effects. Inflammation and compromised barriers may alter diffusion rates and increase irritation risk. Formulations should be adjusted for reduced potency or include soothing agents like aloe vera. Clinical evaluation is needed to determine appropriate use for individuals with sensitive skin (Prausnitz & Langer, 2008).

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