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How do cannabinoid patches compare to oral and inhaled methods in terms of systemic circulation time and bioavailability?

How do cannabinoid patches compare to oral and inhaled methods in terms of systemic circulation time and bioavailability? Cannabinoid patches have a distinct advantage over oral and inhaled methods by bypassing the digestive system and lungs, leading to higher bioavailability. Unlike oral methods, which undergo first-pass metabolism in the liver, and inhalation, which can lead to unpredictable absorption rates, transdermal patches provide a controlled, steady delivery of cannabinoids directly into the bloodstream. This results in longer-lasting effects with more consistent cannabinoid levels in circulation. In terms of systemic circulation time, patches generally provide slower, more sustained effects compared to the rapid onset seen with inhalation or oral consumption.

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