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How do cannabinoid patches interact with different skin layers, and how can this influence both local and systemic effects?

How do cannabinoid patches interact with different skin layers, and how can this influence both local and systemic effects? Cannabinoid patches interact primarily with the epidermis and dermis, the outermost skin layers, to deliver cannabinoids either locally or systemically. The cannabinoids are absorbed through these layers and into the bloodstream, affecting areas near the application site (local effects) or providing widespread therapeutic effects (systemic effects). The interaction depends on the patch's formulation, the cannabinoid's lipophilic properties, and the delivery system used. Targeted formulations can deliver cannabinoids to specific skin layers for more localized effects, while others are designed for deeper absorption to produce systemic benefits.

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