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How does the type of skin (e.g., thin versus thick) at the application site affect cannabinoid absorption from patches?

How does the type of skin (e.g., thin versus thick) at the application site affect cannabinoid absorption from patches? The thickness and composition of the skin at the application site directly influence the absorption rate of cannabinoids. Thinner skin, such as around the wrists or inner arms, allows for easier penetration, leading to faster absorption. Thicker skin, like on the palms or soles, acts as a more substantial barrier, requiring higher cannabinoid concentrations or enhanced delivery systems. Areas with more sebaceous glands may facilitate cannabinoid absorption due to the increased lipid content in these regions.

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