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What are the main receptors involved in the Endocannabinoid System?

What are the main receptors involved in the Endocannabinoid System? The two main receptors in the Endocannabinoid System are CB1 and CB2. CB1 receptors are predominantly located in the brain and central nervous system, where they play a crucial role in regulating mood, cognition, motor control, and pain. CB2 receptors are mainly found in the peripheral tissues and immune system, influencing inflammation and immune responses. Both receptors are activated by endocannabinoids, such as anandamide and 2-AG, which bind to them and initiate various physiological responses. Together, these receptors help the ECS regulate a wide range of bodily functions, promoting overall health and balance.
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