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What are the unique pharmacological properties of CBN compared to other cannabinoids like THC and CBD?

What are the unique pharmacological properties of CBN compared to other cannabinoids like THC and CBD? CBN, or cannabinol, is a cannabinoid with unique pharmacological properties, primarily arising from its mild psychoactive effects and potential sedative properties. Unlike THC, which is a strong agonist at CB1 receptors, CBN has a weaker affinity for these receptors and may exhibit sedative effects without causing significant psychoactivity. Additionally, CBN is believed to enhance the effects of other cannabinoids, particularly in promoting sleep. In contrast, CBD is non-psychoactive and functions primarily as an antagonist at CB1 receptors. The distinct properties of CBN suggest its potential for applications in sleep disorders and as a synergistic component in cannabinoid formulations (Stark et al., 2020).
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