What is the role of the Endocannabinoid System in pain management?
What is the role of the Endocannabinoid System in pain management? The Endocannabinoid System plays a crucial role in pain management by regulating pain perception and response through CB1 and CB2 receptors. CB1 receptors, located in the brain and central nervous system, help modulate pain signals by reducing the release of excitatory neurotransmitters. CB2 receptors, primarily found in peripheral tissues, influence inflammation, which is often associated with pain. Endocannabinoids, like anandamide and 2-AG, are produced by the body in response to injury or inflammation, binding to these receptors to alleviate discomfort. The Endocannabinoid System’s regulation of pain is an essential part of maintaining homeostasis and managing chronic pain conditions.