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What role does the patch material play in ensuring the safe and effective release of cannabinoids over time?

What role does the patch material play in ensuring the safe and effective release of cannabinoids over time? Patch materials must provide controlled permeability, mechanical stability, and biocompatibility to ensure safe cannabinoid release. Polymer-based matrices, such as ethyl cellulose or polyurethane, regulate drug diffusion rates. Occlusive materials enhance hydration and absorption, while breathable films prevent excessive skin irritation. The choice of material directly impacts cannabinoid bioavailability, skin tolerance, and patch durability (Prausnitz & Langer, 2008).

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