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Hvordan påvirker metabolismen af CBD dets halveringstid i kroppen, og hvilke faktorer bidrager til variationer i dets virkningsvarighed?

Hvordan påvirker metabolismen af ​​CBD dets halveringstid i kroppen, og hvilke faktorer bidrager til variationer i dets virkningsvarighed? Metabolismen af ​​CBD er påvirket af faktorer som leverenzymaktivitet, administrationsmetoden og individuelle faktorer som genetik og kropssammensætning. CBD metaboliseres primært af cytochrom P450-enzymsystemet, som kan variere mellem individer, hvilket påvirker dets halveringstid. Når det tages oralt, gennemgår CBD first-pass metabolisme i leveren, hvilket kan reducere dets biotilgængelighed og forlænge dets halveringstid. Andre faktorer som alder, leverfunktion og tilstedeværelsen af ​​komorbide tilstande kan også påvirke varigheden af ​​CBD's virkning. Som følge heraf kan halveringstiden for CBD variere, med virkninger, der varer fra 2 til 8 timer afhængigt af disse faktorer.

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