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Hvordan påvirker tætheden af cannabinoidreceptorer i huden effektiviteten af transdermal cannabinoidplasterabsorption?

Hvordan påvirker tætheden af ​​cannabinoidreceptorer i huden effektiviteten af ​​transdermal cannabinoidplasterabsorption? Tætheden af ​​cannabinoidreceptorer, såsom CB1 og CB2, i huden spiller en afgørende rolle for effektiviteten af ​​transdermal cannabinoidabsorption. Højere receptortætheder i områder af huden, der er målrettet til behandling, kan forbedre bindingen og terapeutiske virkninger af cannabinoider. Områder med en lavere receptortæthed kan kræve højere koncentrationer af cannabinoider eller forbedrede leveringssystemer for at opnå den samme effekt. Patchformuleringer kan optimeres til at matche cannabinoid-levering med fordelingen af ​​disse receptorer for at forbedre terapeutiske resultater.

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