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Kako CBD utječe na epigenetsku regulaciju gena koji reagiraju na stres izazvanu THC-om?

Kako CBD utječe na epigenetsku regulaciju gena koji reagiraju na stres izazvanu THC-om? CBD može utjecati na epigenetsku regulaciju izazvanu THC-om modulirajući ekspresiju gena uključenih u odgovor na stres, posebno onih koje regulira endokanabinoidni sustav. THC tipično izaziva promjene u metilaciji DNK i modifikaciji histona, što može utjecati na ekspresiju gena povezanih sa stresom, poput onih uključenih u osovinu hipotalamus-hipofiza-nadbubrežna žlijezda (HPA). CBD, s druge strane, može ublažiti ove promjene promicanjem homeostaze u endokanabinoidnom sustavu i smanjenjem oksidativnog stresa, što može spriječiti promjene u ekspresiji gena izazvane THC-om. Ova epigenetska modulacija može pomoći u ravnoteži odgovora na stres i smanjiti dugoročni učinak stresa na rad mozga. Kombinirani učinci CBD-a i THC-a mogli bi se potencijalno iskoristiti za ublažavanje negativnih posljedica ekspresije gena povezanih sa stresom.

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