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Kakva je farmakokinetika THC-a kada se primjenjuje različitim metodama dostave?

Kakva je farmakokinetika THC-a kada se primjenjuje različitim metodama dostave? Farmakokinetika THC-a značajno varira ovisno o načinu isporuke. Pušenje ili isparavanje rezultira brzom apsorpcijom u krvotok kroz pluća, s vršnom razinom u plazmi koja se javlja unutar nekoliko minuta i relativno kratko traje djelovanje. Oralna konzumacija (npr. jestiva) dovodi do sporijeg početka zbog metabolizma prvog prolaza u jetri, gdje se THC pretvara u snažni metabolit 11-hidroksi-THC, što rezultira produljenim učinkom. Nasuprot tome, lokalne i transdermalne metode isporučuju THC kroz kožu, pružajući lokalizirane učinke bez značajne psihoaktivnosti. Bioraspoloživost THC-a najveća je inhalacijom, a manja gutanjem zbog metaboličkih procesa, koji utječu na intenzitet i trajanje psihoaktivnih učinaka.

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