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Kakvu ulogu imaju CB2 receptori u psihoaktivnim učincima?

Kakvu ulogu imaju CB2 receptori u psihoaktivnim učincima? CB2 receptori prvenstveno su uključeni u regulaciju imunološkog sustava i upale, a ne psihoaktivne učinke. Uglavnom su smješteni izvan središnjeg živčanog sustava, a njihova je uloga u psihoaktivnosti manje izravna u usporedbi s CB1 receptorima, koji su odgovorni za psihoaktivne učinke THC-a u mozgu. Pokazalo se da aktivacija CB2 receptora ima protuupalni učinak i učinak ublažavanja boli, ali ne izaziva "visoko" koje se obično povezuje s kanabisom. Neki kanabinoidi poput CBD-a mogu komunicirati s CB2 receptorima, pridonoseći terapijskim učincima bez izazivanja psihoaktivnih iskustava. Istraživanja aktivacije CB2 receptora još su u tijeku kako bi se u potpunosti razumjela njegova uloga u učincima posredovanim kanabinoidima.

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