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Koja je uloga procesa detoksikacije faze I i faze II jetre u metabolizmu CBD-a i drugih spojeva kanabisa?

Koja je uloga procesa detoksikacije faze I i faze II jetre u metabolizmu CBD-a i drugih spojeva kanabisa? Procesi detoksikacije faze I u jetri, primarno posredovani enzimima citokroma P450, igraju ključnu ulogu u pretvaranju CBD-a i drugih spojeva kanabisa u metabolite koji su više topljivi u vodi. U fazi II, enzimi konjugacije poput UDP-glukuronoziltransferaza (UGT) dodatno modificiraju te metabolite, čineći ih lakšim za izlučivanje. Ove faze utječu na farmakokinetiku CBD-a, određujući njegovu bioraspoloživost, poluživot i klirens. Varijacije u aktivnosti enzima mogu dovesti do različitih metaboličkih stopa među pojedincima. Ovi procesi pomažu regulirati intenzitet i trajanje učinaka CBD-a u tijelu.

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