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Koje su razlike u psihoaktivnim ishodima između isparenih i oralno konzumiranih kanabinoida?

Koje su razlike u psihoaktivnim ishodima između isparenih i oralno konzumiranih kanabinoida? Psihoaktivni učinci kanabinoida značajno se razlikuju između isparenih i oralnih metoda zbog razlika u bioraspoloživosti i početku djelovanja. Vaporizacija isporučuje kanabinoide poput THC-a izravno u krvotok preko pluća, što dovodi do bržeg nastupa učinaka (u roku od nekoliko minuta), stvarajući neposrednije povišenje. Nasuprot tome, oralna konzumacija (npr. jestivih) zahtijeva probavu i metabolizam prvog prolaza u jetri, što odgađa početak učinaka (obično 30 minuta do 2 sata) i često rezultira intenzivnijim ili dugotrajnijim povišenjem. Oralni kanabinoidi također se metaboliziraju u 11-hidroksi-THC, snažan metabolit koji može proizvesti jače psihoaktivne učinke od THC-a konzumiranog u isparenom obliku. Stoga vaporizacija nastoji proizvesti brže i kontroliranije iskustvo, dok oralna konzumacija dovodi do odgođenog, ali potencijalno intenzivnijeg psihoaktivnog odgovora.

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