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Koje su razlike u učincima THC-a na središnje naspram perifernih CB1 receptora?

Koje su razlike u učincima THC-a na središnje naspram perifernih CB1 receptora? U središnjem živčanom sustavu (CNS), djelovanje THC-a na CB1 receptore prvenstveno je odgovorno za njegove psihoaktivne učinke, uključujući euforiju, oštećenje pamćenja i kognitivne promjene. Vezanje THC-a na CB1 receptore u regijama poput hipokampusa i prefrontalnog korteksa utječe na kognitivne procese i emocionalnu regulaciju. Nasuprot tome, u perifernom živčanom sustavu, učinci THC-a više su povezani s ublažavanjem boli, protuupalnim djelovanjem i regulacijom apetita, zbog CB1 receptora u perifernim tkivima poput probavnog sustava i imunoloških stanica. Ovi učinci mogu varirati među pojedincima ovisno o distribuciji receptora. Sve u svemu, centralni učinci su izraženiji u smislu psihoaktivnosti, dok su periferni učinci više povezani s terapijskim učincima.

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