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In che modo le molecole di cannabinoidi presenti nei cerotti transdermici si diffondono attraverso l'epidermide per raggiungere il derma e altre aree mirate?

In che modo le molecole di cannabinoidi presenti nei cerotti transdermici si diffondono attraverso l'epidermide per raggiungere il derma e altre aree mirate? Le molecole di cannabinoidi presenti nei cerotti transdermici penetrano inizialmente nello strato corneo, lo strato più esterno della pelle, attraverso la diffusione passiva. La formulazione e il sistema di rilascio, come i trasportatori liposomiali o microincapsulati, possono potenziare questo processo migliorando la solubilità e la stabilità dei cannabinoidi. Una volta attraverso l'epidermide, i cannabinoidi entrano nel derma, dove possono interagire con i recettori o entrare nel flusso sanguigno. Il design del cerotto, compreso l'uso di potenziatori di penetrazione, può influenzare la velocità e l'efficienza di questa diffusione.

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