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Care sunt mecanismele neurofarmacologice prin care canabinoizii își exercită efectele anxiolitice? Canabinoizii exercită efecte anxiolitice în primul rând prin interacțiunea lor cu sistemul endocannabinoid, în special receptorii canabinoizi din creier, cum ar fi receptorii CB1. Activarea acestor receptori modulează eliberarea neurotransmițătorilor, ducând la modificări ale căilor legate de anxietate, inclusiv activitate redusă în amigdala și activitate crescută în cortexul prefrontal. De asemenea, canabinoizii pot spori disponibilitatea anandamidei endocannabinoid, contribuind și mai mult la efectele lor anxiolitice. În plus, canabinoizii pot influența sistemul serotoninic, promovând stabilizarea dispoziției și reducând simptomele de anxietate. Înțelegerea acestor mecanisme neurofarmacologice poate ghida dezvoltarea de terapii cu canabinoide țintite pentru tulburările de anxietate (Wilkinson și colab., 2020).
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