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Hvordan kan cannabinoidplastre forbedres for at forbedre absorptionen og samtidig minimere systemiske bivirkninger?

Hvordan kan cannabinoidplastre forbedres for at forbedre absorptionen og samtidig minimere systemiske bivirkninger? Brug af nano-formulering eller mikronåle øger overfladearealet og penetrationen af ​​cannabinoider, hvilket giver mulighed for mere målrettet og effektiv absorption. Inkorporering af cannabinoider med højere affinitet for CB2-receptorer kan fremme lokaliserede effekter med minimal systemisk påvirkning. Formuleringer kan også omfatte gennemtrængningsforstærkere for at optimere cannabinoidtilførsel uden at udløse uønskede bivirkninger. Justering af plastermaterialer og frigivelsesprofiler sikrer vedvarende lavdosisabsorption, hvilket minimerer systemisk eksponering (Paudel et al., 2010).

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