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Come si possono ottimizzare i cerotti ai cannabinoidi per una più rapida insorgenza degli effetti per alleviare il dolore acuto?

Come si possono ottimizzare i cerotti ai cannabinoidi per una più rapida insorgenza degli effetti per alleviare il dolore acuto? È possibile ottenere un’insorgenza più rapida attraverso la formulazione con potenziatori della permeazione, come terpeni, etanolo o nanoparticelle lipidiche. I cerotti assistiti da microaghi consentono ai cannabinoidi di bypassare lo strato corneo, favorendo un rapido assorbimento. L'utilizzo di trasportatori volatili che evaporano rapidamente dalla superficie cutanea può aumentare la biodisponibilità. L'ottimizzazione dello strato adesivo per migliorare l'interazione con la pelle migliora ulteriormente l'efficienza di assorbimento (Prow et al., 2011).

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