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Qual è il ruolo del THC nella modulazione dell'asse ipotalamo-ipofisi-surrene (HPA)?

Qual è il ruolo del THC nella modulazione dell'asse ipotalamo-ipofisi-surrene (HPA)? Il THC può attivare il sistema endocannabinoide, influenzando l’asse HPA, che controlla la risposta del corpo allo stress. Si ritiene che moduli il rilascio di cortisolo, il principale ormone dello stress, riducendo potenzialmente le risposte allo stress e l’ansia. Tuttavia, l’uso cronico di THC può alterare l’asse HPA in modi che possono portare a una disregolazione della produzione di cortisolo, influenzando la gestione dello stress e l’equilibrio emotivo. Questa disregolazione potrebbe contribuire allo stress cronico o influire sulla capacità del corpo di far fronte a futuri fattori di stress. La complessa relazione tra THC e asse HPA svolge un ruolo fondamentale nella comprensione del suo impatto sulla salute mentale.

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