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Quali sono i rischi della dipendenza e dell’astinenza da THC e come si manifestano a livello biochimico?

Quali sono i rischi della dipendenza e dell’astinenza da THC e come si manifestano a livello biochimico? La dipendenza dal THC si verifica a causa di cambiamenti neuroadattativi nei circuiti di ricompensa del cervello, in particolare attraverso la downregulation dei recettori CB1. Si ritiene che i sintomi di astinenza, come irritabilità, disturbi del sonno e ansia, derivino dal tentativo del cervello di ripristinare l'equilibrio in assenza di THC. Dal punto di vista biochimico, ciò include alterazioni nel rilascio di dopamina e nel tono degli endocannabinoidi. L'uso cronico altera l'espressione di vari sistemi di neurotrasmettitori, tra cui GABA e glutammato, che possono contribuire alla disregolazione dell'umore durante l'astinenza. Questi cambiamenti biochimici rendono difficile per gli individui smettere di fumare, portando a ricadute e dipendenza prolungata.

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