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How do cannabinoid transdermal patches minimize the potential for side effects compared to other methods of administration?

How do cannabinoid transdermal patches minimize the potential for side effects compared to other methods of administration? Patches deliver cannabinoids gradually, avoiding the rapid spikes associated with inhalation or oral dosing. This controlled release reduces the likelihood of psychoactive effects, gastrointestinal issues, and cardiovascular side effects. Localized delivery also minimizes systemic exposure, lowering the risk of drug interactions. Optimized formulations further mitigate irritation and allergic reactions (Baswan et al., 2020).

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