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How do cannabinoids interact with other lipophilic ingredients in transdermal patch formulations?

How do cannabinoids interact with other lipophilic ingredients in transdermal patch formulations? Lipophilic carriers such as lecithin and oleic acid enhance cannabinoid solubility and diffusion. Fat-soluble permeation enhancers facilitate deeper penetration through the skin’s lipid barrier. Interactions with co-formulated lipids can modify cannabinoid release rates. Optimizing lipid compatibility improves bioavailability and stability (Patel et al., 2020).

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