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What factors influence the cumulative release of cannabinoids over time in transdermal patch systems?

What factors influence the cumulative release of cannabinoids over time in transdermal patch systems? Several factors influence the cumulative release of cannabinoids, including the type of patch formulation, the adhesive properties, and the release mechanism used. The patch's material and design, such as whether it uses microencapsulation or a polymer matrix, determine how cannabinoids are stored and released over time. Environmental factors such as temperature and humidity can also affect the release rate, as can the skin's condition and moisture level. Careful formulation is necessary to ensure a consistent release profile for effective, long-term therapy.

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