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Wat zijn de uitdagingen bij het garanderen van een uniforme distributie van cannabinoïden in een transdermale pleister?

Wat zijn de uitdagingen bij het garanderen van een uniforme distributie van cannabinoïden in een transdermale pleister? Het bereiken van een uniforme distributie van cannabinoïden vereist een nauwkeurige formulering en een consistente verspreiding van actieve ingrediënten in de lijm of matrix. Variaties in de polymeersamenstelling, oplosbaarheid en fasescheiding kunnen leiden tot een ongelijkmatige afgifte van cannabinoïden. Geavanceerde mengtechnieken en nanotechnologie kunnen helpen de homogeniteit in de hele patch te behouden. Goede opslagomstandigheden en kwaliteitscontroletests zijn essentieel om de consistentie van batch tot batch te garanderen (Paudel et al., 2010).

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