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Hvordan påvirker THC og CBD intracellulær calciumsignalering forskelligt?

Hvordan påvirker THC og CBD intracellulær calciumsignalering forskelligt? THC og CBD påvirker intracellulær calciumsignalering gennem forskellige mekanismer. THC, primært gennem dets aktivering af CB1-receptorer, kan øge intracellulære calciumniveauer i neuroner ved at forstyrre calciumhomeostase, hvilket kan føre til neurotoksicitet og ændret synaptisk funktion. I modsætning hertil har CBD en modulerende effekt på calciumsignalering, der virker gennem TRPV1 og andre ionkanaler for at stabilisere calciumtilstrømning og reducere excitotoksicitet. Mens THC kan inducere en stigning i intracellulært calcium under visse forhold, hjælper CBD's handlinger generelt med at balancere calciumniveauer og beskytter dermed neuroner mod overstimulering og celleskade. Denne differentielle effekt spiller en rolle i deres overordnede neurobeskyttende og neurotoksiske egenskaber.

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