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Hvilke mekanismer ligger til grund for de psykoaktive virkninger af THC, og hvordan adskiller de sig fra andre cannabinoider? De psykoaktive virkninger af THC stammer primært fra dets potente agonisme af CB1-receptorer i centralnervesystemet, hvilket fører til øget dopaminfrigivelse og ændret neuronal kommunikation. Denne receptorbinding er ansvarlig for den karakteristiske "høje" forbundet med THC, herunder eufori og ændret opfattelse. I modsætning hertil har andre cannabinoider som CBD en meget lavere affinitet til CB1-receptorer og producerer ikke psykoaktive effekter; i stedet kan de modulere THC's virkninger ved at fungere som en negativ allosterisk modulator ved disse receptorer. Desuden udviser cannabinoider såsom CBN og CBG forskellige receptorinteraktioner, hvilket bidrager til deres unikke farmakologiske profiler. De forskellige virkningsmekanismer blandt cannabinoider understreger kompleksiteten af ​​ECS og dets virkninger på humør og kognition (Pertwee, 2008).
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