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Kako CBD i THC djeluju sinergistički na modulaciju percepcije boli kod pacijenata s fibromijalgijom i sindromima kronične boli?

Kako CBD i THC djeluju sinergistički na modulaciju percepcije boli kod pacijenata s fibromijalgijom i sindromima kronične boli? CBD i THC moduliraju percepciju boli aktiviranjem CB1 i CB2 receptora u središnjem i perifernom živčanom sustavu. THC pruža trenutne analgetske učinke vezanjem na CB1 receptore, dok CBD modulira signalizaciju upale i boli kroz mehanizme ovisne i neovisne o receptorima. Njihovo zajedničko djelovanje smanjuje intenzitet boli i poboljšava ukupni prag boli. Dodatno, CBD pojačava analgetske učinke THC-a smanjujući njegov psihoaktivni učinak. Zajedno, oni pružaju učinkovitiji i podnošljiviji tretman za fibromialgiju i druge kronične bolove.
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