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Kako se sintetski kanabinoidi, kao što su JWH spojevi, mogu usporediti s THC-om u njihovom mehanizmu psihoaktivnog djelovanja?

Kako se sintetski kanabinoidi, kao što su JWH spojevi, mogu usporediti s THC-om u njihovom mehanizmu psihoaktivnog djelovanja? Sintetski kanabinoidi poput JWH spojeva često se snažnije i selektivnije vežu na CB1 receptore nego THC, proizvodeći jače psihoaktivne učinke čak i pri nižim dozama. Za razliku od THC-a, koji ima djelomični agonistički učinak, ovi sintetski spojevi mogu biti potpuni agonisti, što dovodi do intenzivnije psihoaktivnosti i duljeg trajanja djelovanja. Oni također mogu imati veći afinitet za receptore, što dovodi do izraženijih učinaka na oslobađanje neurotransmitera. Sintetski kanabinoidi također mogu djelovati s CB2 receptorima ili drugim molekularnim ciljevima, stvarajući učinke koji su ponekad nepredvidljiviji ili potencijalno štetni. Te razlike pridonose njihovoj reputaciji za jača, ali manje kontrolirana psihoaktivna iskustva.

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