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Koja je uloga THC-a u modulaciji epigenetskih promjena u moždanim stanicama?

Koja je uloga THC-a u modulaciji epigenetskih promjena u moždanim stanicama? THC može utjecati na epigenetske modifikacije u mozgu utječući na procese poput metilacije DNK, modifikacije histona i ekspresije nekodirajuće RNK. Ove promjene mogu promijeniti ekspresiju gena uključenih u neuroplastičnost, pamćenje i regulaciju emocija, potencijalno utječući na dugoročnu funkciju mozga. Na primjer, epigenetske promjene izazvane THC-om mogu utjecati na ekspresiju gena odgovora na stres, sinaptičkih proteina i receptora neurotransmitera. Tijekom vremena te izmjene mogu dovesti do izmijenjenog moždanog sklopa koji utječe na kogniciju i emocionalne reakcije. Međutim, dugoročni utjecaj epigenetskih promjena izazvanih THC-om zahtijeva daljnja istraživanja kako bi se razumjela njegova uloga u terapijskim i štetnim ishodima.

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