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In che modo i cannabinoidi contenuti nei cerotti transdermici interagiscono con la circolazione sanguigna e i sistemi linfatici?

In che modo i cannabinoidi contenuti nei cerotti transdermici interagiscono con la circolazione sanguigna e i sistemi linfatici? I cannabinoidi assorbiti attraverso la pelle entrano nei capillari dermici e nel sistema linfatico, portando alla distribuzione sistemica. Il sistema linfatico aiuta a bypassare il metabolismo epatico iniziale, migliorando la biodisponibilità rispetto alla somministrazione orale. I cannabinoidi lipofili come CBD, CBG e CBN hanno una maggiore affinità per l'assorbimento linfatico, prolungando il tempo di circolazione. L'entità dell'interazione dipende dalla formulazione, dalla permeabilità cutanea e dai fattori metabolici individuali (Huestis, 2007).

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